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Faculty of Natural and Agricultural Sciences
Department of Microbiology and Plant Pathology
Lyssaviruses
A. Surveillance and molecular phylogeny of the canid variant of rabies virus (RABV)
- Epidemiology of human rabies in South Africa over a 30-year period
- Spread of canid rabies into the Free State province of South Africa
- Molecular epidemiology of wildlife rabies in KwaZulu Natal
B. Molecular phylogeny and the origin of the mongoose variant of rabies virus (gt 1) in Africa
C. Surveillance and molecular phylogeny of rabies-related lyssaviruses
- Molecular phylogeny and epidemiology of the African Mokola and Duvenhage viruses, throughout the continent
- Seroprevalence and epidemiology of lyssaviruses:
in fruit bat species in KwaZulu Natal
in insectivorous bat species in Swaziland
in a variety of bat species in the North West Province
in all host species in specific other African countries including Ghana, Kenya and Rwanda
D. Development of new diagnostic tools for lyssavirus surveillance
- Development of a real-time PCR-method for identification and quantification of African lyssaviruses
- Development of a competitive ELISA for the detection of African lyssavirus antibodies
- Evaluation of a rapid diagnostic immunoassay for use in the detection of lyssaviruses in the developing world.
E. Pathogenesis of lyssaviruses
Pathogenesis of African lyssaviruses in a murine model
Pathogenesis of Lagos bat virus in an experimental fruit bat colony
F. Development of new vaccines for lyssaviruses
Development and evaluation of cross-protective lyssavirus vaccines based on recombinant poxvirus constructs.
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