|
|
|
Faculty of Health Sciences
School of Medicine
Department of Haematology
Immunophenotypic features of secondary haematological dysplasia in HIV positive patients
Cytomorphological dysplasia in the context of HIV infection has been well described in medical literature. Bone marrow investigations are done in HIV patients to assess the activity of the different myeloid cell lineages and to exclude involvement of the marrow by malignant infiltration or opportunistic infections. Bone marrow abnormalities can be seen in all stages of the HIV disease. Dysplasia in one or more cell lineage is the most common abnormal finding in the bone marrow of HIV positive patients. Dysplastic changes is seen in 70% of HIV infected patients and is generally more advanced as the disease progresses. Dyserythropoiesis is seen in approximately 50% of HIV infected patients, and dysplastic features of the granulocytic series and megakaryocytic series are noted in one third of patients. Dysplastic changes can include one, two or all three cell lines and can be morphologically similar to the dysplasia seen in myelodysplastic syndrome.
An improved technique to interpret dysplastic features is needed in these patients as it is necessary to distinguish primary from secondary dysplasia because the treatment and course of the diseases are dramatically different.
|
|
|
|
