Faculty of Health Sciences
School of Medicine
Department of Haematology
Correlation of CRP to toxic granulation in the peripheral blood (adults and children combine with ESR, PCT)
During inflammatory and infectious conditions, mature neutrophils can display cytoplasmic modifications, in the form of toxic granulation. The formation of toxic granulated neutrophils is induced by granulocyte colony stimulating factor (G-CSF). During inflammation, the serum concentrations of G-CSF, as well as plasma interleukin-6 (IL-6), are increased. The serum levels of C-reactive protein (CRP) are also increased in inflammation and in response to stimulation by cytokines, mainly interleukin-6. Previous studies have demonstrated a positive correlation between CRP and the percentages of neutrophils exhibiting toxic granulation during inflammation, and it was also found that the fluctuations of both CRP and toxic granulation of neutrophils were similar. These findings suggest that measurement of toxic granulation of neutrophils is useful in the monitoring of the inflammatory processes. This was done to assess whether grading of toxic granulated neutrophils can be used as a surrogate marker for infection or inflammation.
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